Research paper
Modulation of Membrane Trafficking of AQP5 in the Lens in Response to Changes in Zonular Tension Is Mediated by the Mechanosensitive Channel TRPV1.
About this item
- Title
- Modulation of Membrane Trafficking of AQP5 in the Lens in Response to Changes in Zonular Tension Is Mediated by the Mechanosensitive Channel TRPV1.
- Content partner
- The University of Auckland Library
- Collection
- ResearchSpace@Auckland
- Description
In mice, the contraction of the ciliary muscle via the administration of pilocarpine reduces the zonular tension applied to the lens and activates the TRPV1-mediated arm of a dual feedback system that regulates the lens' hydrostatic pressure gradient. In the rat lens, this pilocarpine-induced reduction in zonular tension also causes the water channel AQP5 to be removed from the membranes of fiber cells located in the anterior influx and equatorial efflux zones. Here, we determined whether thi...
- Format
- Research paper
- Research format
- Journal article
- Date created
- 2023-05
- Creator
- Petrova, Rosica S / Nair, Nikhil / Bavana, Nandini / Chen, Yadi / Schey, Kevin L / Donaldson, Paul J
- URL
- https://hdl.handle.net/2292/65660
- Related subjects
- Lens, Crystalline / Membranes / Animals / Mice / Rats / Pilocarpine / Aquaporins / TRPV Cation Channels / Aquaporin 5 / AQP5 / TRPV1 / lens / lens surface pressure / water transport / 3101 Biochemistry and Cell Biology / 31 Biological Sciences / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 3107 Microbiology / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences
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