Modulation of Membrane Trafficking of AQP5 in the Lens in Response to Changes in Zonular Tension Is Mediated by the Mechanosensitive Channel TRPV1.

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Title

Modulation of Membrane Trafficking of AQP5 in the Lens in Response to Changes in Zonular Tension Is Mediated by the Mechanosensitive Channel TRPV1.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

In mice, the contraction of the ciliary muscle via the administration of pilocarpine reduces the zonular tension applied to the lens and activates the TRPV1-mediated arm of a dual feedback system that regulates the lens' hydrostatic pressure gradient. In the rat lens, this pilocarpine-induced reduction in zonular tension also causes the water channel AQP5 to be removed from the membranes of fiber cells located in the anterior influx and equatorial efflux zones. Here, we determined whether thi...

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Format

Research paper

Research format

Journal article

Date created

2023-05

Creator

Petrova, Rosica S / Nair, Nikhil / Bavana, Nandini / Chen, Yadi / Schey, Kevin L / Donaldson, Paul J

URL

https://hdl.handle.net/2292/65660

Related subjects

Lens, Crystalline / Membranes / Animals / Mice / Rats / Pilocarpine / Aquaporins / TRPV Cation Channels / Aquaporin 5 / AQP5 / TRPV1 / lens / lens surface pressure / water transport / 3101 Biochemistry and Cell Biology / 31 Biological Sciences / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 3107 Microbiology / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

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