Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus.

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Title

Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Neuroinflammation is a key component of virtually all neurodegenerative diseases, preceding neuronal loss and associating directly with cognitive impairment. Neuroinflammatory signals can originate and be amplified at barrier tissues such as brain vasculature, surrounding meninges and the choroid plexus. We designed a high content screening system to target inflammation in human brain-derived cells of the blood-brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers...

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Format

Research paper

Research format

Journal article

Date created

2021-02

Creator

Jansson, Deidre / Dieriks, Victor Birger / Rustenhoven, Justin / Smyth, Leon CD / Scotter, Emma / Aalderink, Miranda / Feng, Sheryl / Johnson, Rebecca / Schweder, Patrick / Mee, Edward / Heppner, Peter / Turner, Clinton / Curtis, Maurice / Faull, Richard / Dragunow, Mike

URL

https://hdl.handle.net/2292/65751

Related subjects

Blood-Brain Barrier / Pericytes / Choroid Plexus / Meninges / Cells, Cultured / Endothelial Cells / Humans / Inflammation / Digoxin / Lanatosides / Anti-Inflammatory Agents / Inflammation Mediators / Tissue Culture Techniques / Drug Evaluation, Preclinical / High-Throughput Screening Assays / 32 Biomedical and Clinical Sciences / Neurosciences / Cardiovascular / 5 Development of treatments and therapeutic interventions / 2 Aetiology / 5.1 Pharmaceuticals / 2.1 Biological and endogenous factors / Neurological / 3 Good Health and Well Being / Science & Technology / Life Sciences & Biomedicine / Biology / Multidisciplinary Sciences / Life Sciences & Biomedicine - Other Topics / Science & Technology - Other Topics / 31 Biological sciences

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