Multimodal imaging shows fibrosis architecture and action potential dispersion are predictors of arrhythmic risk in spontaneous hypertensive rats.

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Title

Multimodal imaging shows fibrosis architecture and action potential dispersion are predictors of arrhythmic risk in spontaneous hypertensive rats.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Hypertensive heart disease (HHD) increases risk of ventricular tachycardia (VT) and ventricular fibrillation (VF). The roles of structural vs. electrophysiological remodelling and age vs. disease progression are not fully understood. This cross-sectional study of cardiac alterations through HHD investigates mechanistic contributions to VT/VF risk. Risk was electrically assessed in Langendorff-perfused, spontaneously hypertensive rat hearts at 6, 12 and 18 months, and paced optical membrane vo...

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Format

Research paper

Research format

Journal article

Date created

2022-09

Creator

Khwaounjoo, Prashanna / Sands, Gregory B / LeGrice, Ian J / Ramulgun, Girish / Ashton, Jesse L / Montgomery, Johanna M / Gillis, Anne M / Smaill, Bruce H / Trew, Mark L

URL

https://hdl.handle.net/2292/65906

Related subjects

Pericardium / Animals / Rats, Inbred SHR / Rats / Tachycardia, Ventricular / Ventricular Fibrillation / Fibrosis / Cross-Sectional Studies / Action Potentials / Arrhythmias, Cardiac / Multimodal Imaging / 3D structural imaging / hypertensive heart disease / optical mapping / ventricular arrhythmia / 3208 Medical Physiology / 32 Biomedical and Clinical Sciences / Heart Disease / Cardiovascular / Prevention / 2 Aetiology / 2.1 Biological and endogenous factors / Science & Technology / Life Sciences & Biomedicine / Neurosciences / Physiology / Neurosciences & Neurology / LEFT-VENTRICULAR HYPERTROPHY / HEART-FAILURE / CONDUCTION-VELOCITY / CARDIAC TISSUE / SUSCEPTIBILITY / VULNERABILITY / PROGRESSION / MYOCYTES / TACHYCARDIA / MYOCARDIUM / 06 Biological Sciences / 11 Medical and Health Sciences / 31 Biological sciences / 42 Health sciences

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