DNA-Binding Anticancer Drugs: One Target, Two Actions

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Title

DNA-Binding Anticancer Drugs: One Target, Two Actions

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acute lymphoblastic leukaemia. In 1984, the enzyme DNA topoisomerase II was identified as a molecular target for amsacrine, acting to poison this enzyme and to induce DNA double-strand breaks. One of the main challenges in the 1980s was to determine w...

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Format

Research paper

Research format

Journal article

Date created

2021-01

Creator

Baguley, Bruce C / Drummond, Catherine J / Chen, Ying Yi / Finlay, Graeme J

URL

https://hdl.handle.net/2292/66139

Related subjects

Chromatids / Animals / Humans / Mice / Lung Neoplasms / Naphthyridines / Amsacrine / DNA Topoisomerases, Type II / Neoplasm Proteins / DNA, Neoplasm / Antineoplastic Agents / Anaphase / Chromosome Segregation / History, 20th Century / History, 21st Century / Topoisomerase II Inhibitors / Adenocarcinoma of Lung / DNA binding / antitumour / cell cycle / immunogenic cell death / pharmacokinetics / topoisomerase / 3404 Medicinal and Biomolecular Chemistry / 3405 Organic Chemistry / 34 Chemical Sciences / Rare Diseases / Cancer / Genetics / 5.1 Pharmaceuticals / 5 Development of treatments and therapeutic interventions / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / 0304 Medicinal and Biomolecular Chemistry / 0305 Organic Chemistry / 0307 Theoretical and Computational Chemistry

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