Differential Effects of Hypoxia versus Hyperoxia or Physoxia on Phenotype and Energy Metabolism in Human Chondrocytes from Osteoarthritic Compared to Macroscopically Normal Cartilage

About this item

Title

Differential Effects of Hypoxia versus Hyperoxia or Physoxia on Phenotype and Energy Metabolism in Human Chondrocytes from Osteoarthritic Compared to Macroscopically Normal Cartilage

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Chondrocyte phenotype and energy metabolism are altered in osteoarthritis (OA). However, most studies characterising the change in human chondrocyte behaviour in OA have been conducted in supraphysiological oxygen concentrations. The purpose of this study was to compare phenotype and energy metabolism in chondrocytes from macroscopically normal (MN) and OA cartilage maintained in 18.9% (standard tissue culture), 6% (equivalent to superficial zone of cartilage in vivo) or 1% oxygen (equivalent...

Read more

Format

Research paper

Research format

Journal article

Date created

2023-04

Creator

Jain, Lekha / Bolam, Scott M / Monk, A Paul / Munro, Jacob T / Chen, Even / Tamatea, Jade / Dalbeth, Nicola / Poulsen, Raewyn C

URL

https://hdl.handle.net/2292/66057

Related subjects

Cartilage, Articular / Cells, Cultured / Chondrocytes / Humans / Osteoarthritis / Hyperoxia / Oxygen / Energy Metabolism / Phenotype / Hypoxia / MMP13 / SOX9 / aggrecan / chondrocyte / glycolysis / oxidative phosphorylation / physoxia / type II collagen / 3101 Biochemistry and Cell Biology / 31 Biological Sciences / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 3107 Microbiology / Arthritis / Aging / 2 Aetiology / 2.1 Biological and endogenous factors / Musculoskeletal / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / II COLLAGEN-SYNTHESIS / GENE-EXPRESSION / MATRIX / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

What is the copyright status of this item?

Share, Modify, Use commercially

See below for specifics about how you may use this item.

More Information

The University of Auckland Library has this to say about the rights status of this item:

Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.

You can learn more about the rights status of this item at:

• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
• https://creativecommons.org/licenses/by/4.0/
• http://purl.org/eprint/accessRights/OpenAccess

What can I do with this item?

You must always check with The University of Auckland Library to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

Share it

This item is suitable for copying and sharing with others, without further permission.

Modify it

This item is suitable for modifying, remixing and building upon, without further permission.

Use it commercially

This item is suitable for commercial use, without further permission.