Therapeutic Hypothermia Attenuates Cortical Interneuron Loss after Cerebral Ischemia in Near-Term Fetal Sheep

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Title

Therapeutic Hypothermia Attenuates Cortical Interneuron Loss after Cerebral Ischemia in Near-Term Fetal Sheep

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Therapeutic hypothermia significantly improves outcomes after neonatal hypoxic-ischemic (HI) encephalopathy but is only partially protective. There is evidence that cortical inhibitory interneuron circuits are particularly vulnerable to HI and that loss of interneurons may be an important contributor to long-term neurological dysfunction in these infants. In the present study, we examined the hypothesis that the duration of hypothermia has differential effects on interneuron survival after HI...

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Format

Research paper

Research format

Journal article

Date created

2023-02

Creator

Yang, Panzao / Davidson, Joanne O / Zhou, Kelly Q / Wilson, Rani / Wassink, Guido / Prasad, Jaya D / Bennet, Laura / Gunn, Alistair J / Dean, Justin M

URL

https://hdl.handle.net/2292/66135

Related subjects

Interneurons / Animals / Sheep / Cerebral Infarction / Hypoxia-Ischemia, Brain / Ischemia / Parvalbumins / Hypothermia, Induced / EEG / cerebral cortex / cooling / interneuron / neonatal / therapeutic hypothermia / 3101 Biochemistry and Cell Biology / 31 Biological Sciences / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 3107 Microbiology / Neurosciences / Brain Disorders / Pediatric / Stroke / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / CALCIUM-BINDING PROTEINS / GABAERGIC INTERNEURONS / PARVALBUMIN IMMUNOREACTIVITY / NEURONAL SUBPOPULATIONS / INHIBITORY INTERNEURONS / POSTNATAL-DEVELOPMENT / NEUROTROPHIC FACTOR / PREFRONTAL CORTEX / AUDITORY-CORTEX / VISUAL-CORTEX / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

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