An open-label pilot trial of faecal microbiome transfer to restore the gut microbiome in anorexia nervosa: protocol

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Title

An open-label pilot trial of faecal microbiome transfer to restore the gut microbiome in anorexia nervosa: protocol

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

IntroductionIndividuals with anorexia nervosa (AN) harbour distinct gut microbiomes compared with healthy individuals, which are sufficient to induce weight loss and anxiety-like behaviours when transplanted into germ-free mice. We hypothesise that faecal microbiome transfer (FMT) from healthy donors would help restore the gut microbiome of individuals with AN, which in turn, may aid patient recovery.MethodsWe aim to conduct an open-label pilot study in 20 females aged 16-32 years in Auckland...

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Format

Research paper

Research format

Journal article

Date created

2023-07

Creator

Wilson, Brooke C / Derraik, José GB / Albert, Benjamin B / Leong, Karen SW / Tweedie-Cullen, Ry Y / Creagh, Christine / Depczynski, Marysia / Edwards, Taygen / Vatanen, Tommi / Thabrew, Hiran / Cutfield, Wayne S / O'Sullivan, Justin M

URL

https://hdl.handle.net/2292/66036

Related subjects

Humans / Capsules / Pilot Projects / Anorexia Nervosa / Adolescent / Adult / Female / Young Adult / Microbiota / Gastrointestinal Microbiome / eating disorders / gastroenterology / microbiology / therapeutics / transplant medicine / 32 Biomedical and Clinical Sciences / Digestive Diseases / Clinical Research / Prevention / Brain Disorders / Clinical Trials and Supportive Activities / Mental Health / Anorexia / Nutrition / Oral and gastrointestinal / 3 Good Health and Well Being / Science & Technology / Life Sciences & Biomedicine / Medicine, General & Internal / General & Internal Medicine / INTESTINAL MICROBIOTA / INSULIN SENSITIVITY / EATING-DISORDERS / TRANSPLANTATION / ANXIETY / PERMEABILITY / INDIVIDUALS / DEPRESSION / 1103 Clinical Sciences / 1117 Public Health and Health Services / 1199 Other Medical and Health Sciences / 42 Health sciences / 52 Psychology

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