Fragment-based and structure-guided discovery of perforin inhibitors

About this item

Title

Fragment-based and structure-guided discovery of perforin inhibitors

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Perforin is a pore-forming protein whose normal function enables cytotoxic T and natural killer (NK) cells to kill virus-infected and transformed cells. Conversely, unwanted perforin activity can also result in auto-immune attack, graft rejection and aberrant responses to pathogens. Perforin is critical for the function of the granule exocytosis cell death pathway and is therefore a target for drug development. In this study, by screening a fragment library using NMR and surface plasmon reson...

Read more

Format

Research paper

Research format

Journal article

Date created

2023-09

Creator

Jose, Jiney / Law, Ruby HP / Leung, Eleanor WW / Wai, Dorothy CC / Akhlaghi, Hedieh / Chandrashekaran, Indu R / Caradoc-Davies, Tom T / Voskoboinik, Ilia / Feutrill, John / Middlemiss, David / Jeevarajah, Devadharshini / Bashtannyk-Puhalovich, Tanya / Giddens, Anna C / Lee, Tet Woo / Jamieson, Stephen MF / Trapani, Joseph A / Whisstock, James C / Spicer, Julie A / Norton, Raymond S

URL

https://hdl.handle.net/2292/66050

Related subjects

32 Biomedical and Clinical Sciences / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 3204 Immunology / Rare Diseases / 1.1 Normal biological development and functioning / 5 Development of treatments and therapeutic interventions / 5.1 Pharmaceuticals / 1 Underpinning research / Inflammatory and immune system / 0304 Medicinal and Biomolecular Chemistry / 0305 Organic Chemistry / 1115 Pharmacology and Pharmaceutical Sciences / 3214 Pharmacology and pharmaceutical sciences / 3405 Organic chemistry

What is the copyright status of this item?

Share, Modify, Use commercially

See below for specifics about how you may use this item.

More Information

The University of Auckland Library has this to say about the rights status of this item:

Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.

You can learn more about the rights status of this item at:

• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
• https://creativecommons.org/licenses/by/4.0/
• http://purl.org/eprint/accessRights/OpenAccess

What can I do with this item?

You must always check with The University of Auckland Library to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

Share it

This item is suitable for copying and sharing with others, without further permission.

Modify it

This item is suitable for modifying, remixing and building upon, without further permission.

Use it commercially

This item is suitable for commercial use, without further permission.