From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research

About this item

Title

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Huntington's disease (HD) is a debilitating neurodegenerative genetic disorder caused by an expanded polyglutamine-coding (CAG) trinucleotide repeat in the huntingtin (HTT) gene. HD behaves as a highly penetrant dominant disorder likely acting through a toxic gain of function by the mutant huntingtin protein. Widespread cellular degeneration of the medium spiny neurons of the caudate nucleus and putamen are responsible for the onset of symptomology that encompasses motor, cognitive, and behav...

Read more

Format

Research paper

Research format

Journal article

Date created

2023-08

Creator

Jiang, Andrew / Handley, Renee R / Lehnert, Klaus / Snell, Russell G

URL

https://hdl.handle.net/2292/66132

Related subjects

Caudate Nucleus / Humans / Huntington Disease / Heredodegenerative Disorders, Nervous System / Dopamine / Cytopathogenic Effect, Viral / Mutant Proteins / Huntington’s disease / pathogenesis / therapeutics / 31 Biological Sciences / 3105 Genetics / Orphan Drug / Neurodegenerative / Neurosciences / Rare Diseases / Genetics / Huntington's Disease / Brain Disorders / 2 Aetiology / 2.1 Biological and endogenous factors / Neurological / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences / 3101 Biochemistry and cell biology / 3107 Microbiology / 3404 Medicinal and biomolecular chemistry

What is the copyright status of this item?

Share, Modify, Use commercially

See below for specifics about how you may use this item.

More Information

The University of Auckland Library has this to say about the rights status of this item:

Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.

You can learn more about the rights status of this item at:

• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
• https://creativecommons.org/licenses/by/4.0/
• http://purl.org/eprint/accessRights/OpenAccess

What can I do with this item?

You must always check with The University of Auckland Library to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

Share it

This item is suitable for copying and sharing with others, without further permission.

Modify it

This item is suitable for modifying, remixing and building upon, without further permission.

Use it commercially

This item is suitable for commercial use, without further permission.