Better post-operative outcomes at 1-year follow-up are associated with lower levels of pre-operative synovitis and higher levels of IL-6 and VEGFA in unicompartmental knee arthroplasty patients

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Title

Better post-operative outcomes at 1-year follow-up are associated with lower levels of pre-operative synovitis and higher levels of IL-6 and VEGFA in unicompartmental knee arthroplasty patients

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Purpose Osteoarthritis (OA) is associated with infammation, and residual infammation may infuence outcomes following knee arthroplasty. This may be more relevant for patients undergoing unicompartmental knee arthroplasty (UKA) due to larger remaining areas of native tissue. This study aimed to: (1) characterise infammatory profles for medial UKA patients and (2) investigate whether infammation markers are associated with post-operative outcomes. Methods This prospective, observational study h...

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Format

Research paper

Research format

Journal article

Date created

2023-10

Creator

Tay, Mei Lin / Bolam, Scott M / Monk, A Paul / McGlashan, Sue R / Young, Simon W / Matthews, Brya G

URL

https://hdl.handle.net/2292/66177

Related subjects

Knee Joint / Humans / Osteoarthritis, Knee / Synovitis / Inflammation / Vascular Endothelial Growth Factor A / Interleukin-6 / Treatment Outcome / Arthroplasty, Replacement, Knee / Retrospective Studies / Follow-Up Studies / Prospective Studies / Knee Prosthesis / Biomarkers / Cytokine / Inflammatory marker / Medial UKA / OA phenotype / Osteoarthritis / Patient selection / UKA / Unicompartmental knee arthroplasty / 32 Biomedical and Clinical Sciences / 3202 Clinical Sciences / Clinical Research / Chronic Pain / Arthritis / Pain Research / 2.1 Biological and endogenous factors / 2 Aetiology / Inflammatory and immune system / Musculoskeletal / 3 Good Health and Well Being / Science & Technology / Life Sciences & Biomedicine / Orthopedics / Sport Sciences / Surgery / FLUID / PROFILES / CYTOKINES / PLASMA / GRADE / SERUM / 1103 Clinical Sciences / 1106 Human Movement and Sports Sciences / 4201 Allied health and rehabilitation science / 4207 Sports science and exercise

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