Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

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Title

Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Dysregulation of retinal function in the early stages of light-induced retinal degeneration involves pannexins and connexins. These two types of proteins may contribute to channels that release ATP, leading to activation of the inflammasome pathway, spread of inflammation and retinal dysfunction. However, the effect of pannexin channel block alone or block of both pannexin channels and connexin hemichannels in parallel on retinal activity in vivo is unknown. In this study, the pannexin channe...

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Format

Research paper

Research format

Journal article

Date created

2021-02

Creator

Mat Nor, Mohd N / Rupenthal, Ilva D / Green, Colin R / Acosta, Monica L

URL

https://hdl.handle.net/2292/66056

Related subjects

Retina / Animals / Rats / Rats, Sprague-Dawley / Retinal Diseases / Inflammation / Benzamides / Probenecid / Benzopyrans / Connexins / Connexin 43 / Nerve Tissue Proteins / Light / Female / Male / connexin43 / electroretinogram / light damage / pannexin / tonabersat / 3101 Biochemistry and Cell Biology / 31 Biological Sciences / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 3107 Microbiology / Eye Disease and Disorders of Vision / Neurosciences / 5 Development of treatments and therapeutic interventions / 5.1 Pharmaceuticals / Eye / Neurological / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / GAP-JUNCTION PROTEINS / INJURY / ACTIVATION / EXPRESSION / APOPTOSIS / DAMAGE / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

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