P1 Glutamine isosteres in the design of inhibitors of 3C/3CL protease of human viruses of the Pisoniviricetes class

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Title

P1 Glutamine isosteres in the design of inhibitors of 3C/3CL protease of human viruses of the Pisoniviricetes class

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Viral infections are one of the leading causes of acute morbidity in humans and much endeavour has been made by the synthetic community for the development of drugs to treat associated diseases. Peptide-based enzyme inhibitors, usually short sequences of three or four residues, are one of the classes of compounds currently under development for enhancement of their activity and pharmaceutical properties. This review reports the advances made in the design of inhibitors targeting the family of...

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Format

Research paper

Research format

Journal article

Date created

2023-08

Creator

Stubbing, Louise A / Hubert, Jonathan G / Bell-Tyrer, Joseph / Hermant, Yann O / Yang, Sung Hyun / McSweeney, Alice M / McKenzie-Goldsmith, Geena M / Ward, Vernon K / Furkert, Daniel P / Brimble, Margaret A

URL

https://hdl.handle.net/2292/66117

Related subjects

3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 5 Development of treatments and therapeutic interventions / 5.1 Pharmaceuticals / Infection / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry

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