Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway

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Title

Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Renal fibrosis is a main cause of end-stage renal disease. Clinically, there is no beneficial treatment that can effectively reverse the progressive loss of renal function. We recently synthesized a novel proteolysis-resistant cyclic helix B peptide (CHBP) that exhibits promising renoprotective effects. In this study, we evaluated the effect of CHBP on renal fibrosis in an in vivo ischemia reperfusion injury (IRI) model and in vitro TGF-β-stimulated tubular epithelial cells (TCMK-1 and HK-2) ...

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Format

Research paper

Research format

Journal article

Date created

2015-11

Creator

Yang, Cheng / Cao, Ye / Zhang, Yi / Li, Long / Xu, Ming / Long, Yaqiu / Rong, Ruiming / Zhu, Tongyu

URL

https://hdl.handle.net/2292/66176

Related subjects

Kidney / Animals / Mice, Inbred BALB C / Humans / Mice / Kidney Diseases / Reperfusion Injury / Fibrosis / Peptides, Cyclic / Transforming Growth Factor beta / Male / Proto-Oncogene Proteins c-akt / Forkhead Transcription Factors / Phosphatidylinositol 3-Kinases / Epithelial-Mesenchymal Transition / Forkhead Box Protein O3 / 32 Biomedical and Clinical Sciences / Kidney Disease / 1.1 Normal biological development and functioning / 1 Underpinning research / 2 Aetiology / 2.1 Biological and endogenous factors / Science & Technology / Life Sciences & Biomedicine / Medicine, Research & Experimental / Research & Experimental Medicine / Cyclic helix B peptide / Renal ischemia reperfusion injury / Akt / FoxO3 / NAKED CASPASE-3 SIRNA / ACUTE KIDNEY INJURY / ISCHEMIA/REPERFUSION INJURY / AUTOTRANSPLANT KIDNEYS / INFLAMMATION / ACTIVATION / DISEASE / MODEL / 11 Medical and Health Sciences / 42 Health sciences

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