Proinflammatory cytokines trigger biochemical and neurochemical changes in mouse retinal explants exposed to hyperglycemic conditions

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Title

Proinflammatory cytokines trigger biochemical and neurochemical changes in mouse retinal explants exposed to hyperglycemic conditions

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Purpose: Diabetic retinopathy (DR) is one of the most frequent complications of diabetes affecting the retina and eventually causing vision impairment. Emerging evidence suggests that inflammation plays a vital role in DR progression. In this study, we evaluated the early biochemical and neurochemical changes in mouse retinal explants to understand the contribution of proinflammatory cytokines to disease progression. Methods: DR was modeled in vitro by incubating mouse retinal explants in a p...

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Format

Research paper

Research format

Journal article

Date created

2020-01

Creator

Shivashankar, Gaganashree / Lim, Julie C / Acosta, Monica L

URL

https://hdl.handle.net/2292/66165

Related subjects

Retina / Cells, Cultured / Animals / Mice, Inbred C57BL / Mice / Diabetic Retinopathy / Hyperglycemia / gamma-Aminobutyric Acid / Glucose / Glutamic Acid / Glutamine / Glycine / Tumor Necrosis Factor-alpha / Adenosine Triphosphate / Cytokines / Immunohistochemistry / Energy Metabolism / Female / Interleukin-1beta / 32 Biomedical and Clinical Sciences / 3212 Ophthalmology and Optometry / Diabetes / Eye Disease and Disorders of Vision / Prevention / Neurosciences / Nutrition / Eye / Metabolic and endocrine / 7 Affordable and Clean Energy / Science & Technology / Life Sciences & Biomedicine / Biochemistry & Molecular Biology / Ophthalmology / NECROSIS-FACTOR-ALPHA / DIABETIC-RETINOPATHY / ENERGY-METABOLISM / ENDOTHELIAL-CELLS / GLUTAMATE UPTAKE / GLUCOSE-UPTAKE / BRAIN / TRANSPORT / INNER / GLUT1 / 1113 Opthalmology and Optometry / Biomedical / Basic Science

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