Orally Delivered Connexin43 Hemichannel Blocker, Tonabersat, Inhibits Vascular Breakdown and Inflammasome Activation in a Mouse Model of Diabetic Retinopathy

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Title

Orally Delivered Connexin43 Hemichannel Blocker, Tonabersat, Inhibits Vascular Breakdown and Inflammasome Activation in a Mouse Model of Diabetic Retinopathy

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with pronounced inflammation arising from the activation of a nucleotide-binding and oligomerization domain-like receptor (NLR) protein 3 (NLRP3) inflammasome. Cell culture models have shown that a connexin43 hemichannel blocker can prevent inflammasome activation in DR. The aim of this study was to evaluate the ocular safety and efficacy of tonabersat, an orally bioavailable connexin43 hemichannel blocker, to ...

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Format

Research paper

Research format

Journal article

Date created

2023-02

Creator

Mugisho, Odunayo O / Aryal, Jyoti / Shorne, Avik / Lyon, Heather / Acosta, Monica L / Green, Colin R / Rupenthal, Ilva D

URL

https://hdl.handle.net/2292/66133

Related subjects

Animals / Mice, Inbred NOD / Mice / Diabetic Retinopathy / Disease Models, Animal / Inflammation / Benzamides / Connexin 43 / Administration, Oral / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / inflammasome / retina / vascular breakdown / 3101 Biochemistry and Cell Biology / 31 Biological Sciences / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 3107 Microbiology / Eye Disease and Disorders of Vision / Diabetes / Neurosciences / 5.1 Pharmaceuticals / 5 Development of treatments and therapeutic interventions / Eye / Metabolic and endocrine / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / VESICLE-ASSOCIATED PROTEIN / ANTIGEN PAL-E / NLRP3 INFLAMMASOME / DANGER SIGNAL / EXPRESSION / PATHWAY / VEGF / TARGET / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

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