Proinflammatory Cytokines Trigger the Onset of Retinal Abnormalities and Metabolic Dysregulation in a Hyperglycemic Mouse Model

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Title

Proinflammatory Cytokines Trigger the Onset of Retinal Abnormalities and Metabolic Dysregulation in a Hyperglycemic Mouse Model

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The University of Auckland Library

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Description

Purpose. Recent evidence has shown that retinal infammation is a key player in diabetic retinopathy (DR) pathogenesis. To further understand and validate the metabolic biomarkers of DR, we investigated the efect of intravitreal proinfammatory cytokines on the retinal structure, function, and metabolism in an in vivo hyperglycemic mouse model. Methods. C57Bl/6 mice were rendered hyperglycemic within one week of administration of a single high-dose intraperitoneal injection of streptozotocin, w...

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Format

Research paper

Research format

Journal article

Date created

2023-01

Creator

Shivashankar, Gaganashree / Lim, Julie C / Acosta, Monica L

URL

https://hdl.handle.net/2292/66152

Related subjects

32 Biomedical and Clinical Sciences / 3212 Ophthalmology and Optometry / Neurosciences / Eye Disease and Disorders of Vision / Diabetes / Eye / Metabolic and endocrine / Science & Technology / Life Sciences & Biomedicine / Ophthalmology / OPTICAL COHERENCE TOMOGRAPHY / DIABETIC-RETINOPATHY / HYPERREFLECTIVE FOCI / GLUTAMINE-SYNTHETASE / INFLAMMATION / MICE / EYES / NEURODEGENERATION / DYSFUNCTION / HEMOGLOBIN / 1113 Opthalmology and Optometry

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