Developing Novel Lipidated Glycotherapeutics

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Title

Developing Novel Lipidated Glycotherapeutics

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

<strong>This thesis is comprised of two distinct sections.</strong>The first section, Chapters 2 to 4, focuses on developing novel dendritic heparan sulfate (HS) mimetics for potential use as anti-cancer and anti-viral agents. This includes the design, synthesis, and purification of sulfated mimetics and their bioisosteric analogues.HS is a naturally occurring glycosaminoglycan (GAG) widely present in mammalian tissues. Its complex structure and negative charge allow it to interact with a ple...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2023

Creator

Arran Stewart

URL

https://figshare.com/articles/thesis/Developing_Novel_Lipidated_Glycotherapeutics/24707799

Related subjects

Medicinal and biomolecular chemistry not elsewhere classified / Organic chemical synthesis / Organic Chemistry / Medicinal Chemistry / Organic Synthesis / Heparan Sulfate Mimetics / Native Chemical Ligation / Heparan Sulfate / Heparanase / Expanding knowledge in the chemical sciences / Degree Discipline: Chemistry / Degree Level: Doctoral / Degree Name: Doctor of Philosophy / Unit: Ferrier Research Institute

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