Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity

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Title

Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Hematopoietic stem and progenitor cells (HSPCs) respond to infection by proliferating and generating in-demand neutrophils through a process called emergency granulopoiesis (EG). Recently, infection-induced changes in HSPCs have also been shown to underpin the longevity of trained immunity, where they generate innate immune cells with enhanced responses to subsequent microbial threats. Using larval zebrafish to live image neutrophils and HSPCs, we show that infection-experienced HSPCs generat...

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Format

Research paper

Research format

Journal article

Date created

2023-09

Creator

Darroch, Hannah / Keerthisinghe, Pramuk / Sung, Yih Jian / Rolland, Leah / Prankerd-Gough, Anneke / Crosier, Philip S / Astin, Jonathan W / Hall, Christopher J

URL

https://hdl.handle.net/2292/66643

Related subjects

Hematopoietic Stem Cells / Animals / Zebrafish / Bacterial Infections / Reactive Oxygen Species / Larva / Trained Immunity / 3109 Zoology / 31 Biological Sciences / Emerging Infectious Diseases / Prevention / Stem Cell Research / Biodefense / Infectious Diseases / Vaccine Related / 2.1 Biological and endogenous factors / 2 Aetiology / Infection / Inflammatory and immune system / 3 Good Health and Well Being / Science & Technology / Multidisciplinary Sciences / Science & Technology - Other Topics / HEMATOPOIETIC STEM-CELLS / C/EBP-BETA / MYELOPOIESIS / EXPRESSION / COMPONENT / MEMORY / MODEL / RUNX1

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