Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence

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Title

Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Gout is caused by elevated serum urate leading to the deposition of monosodium urate (MSU) crystals that can trigger episodes of acute inflammation. Humans are sensitive to developing gout because they lack a functional urate-metabolizing enzyme called uricase/urate oxidase (encoded by the UOX gene). A hallmark of long-standing disease is tophaceous gout, characterized by the formation of tissue-damaging granuloma-like structures ('tophi') composed of densely packed MSU crystals and immune ce...

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Format

Research paper

Research format

Journal article

Date created

2022-11

Creator

Linnerz, Tanja / Sung, Yih Jian / Rolland, Leah / Astin, Jonathan W / Dalbeth, Nicola / Hall, Christopher J

URL

https://hdl.handle.net/2292/66737

Related subjects

Animals / Zebrafish / Humans / Gout / Inflammation / Uric Acid / Urate Oxidase / CRISPR/Cas9 / MSU crystals / hyperuricemia / urate / uricase / 31 Biological Sciences / 3105 Genetics / 2.1 Biological and endogenous factors / 2 Aetiology / Inflammatory and immune system / Science & Technology / Life Sciences & Biomedicine / Genetics & Heredity / CRISPR / Cas9 / ASYMPTOMATIC HYPERURICEMIA / PLAIN RADIOGRAPHY / TOPHACEOUS GOUT / BONE EROSION / ACID / OXIDASE / MODEL / DEPOSITION / MORTALITY / TOPHUS / 0604 Genetics

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