Growth hormone receptor agonists and antagonists: From protein expression and purification to long-acting formulations.

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Title

Growth hormone receptor agonists and antagonists: From protein expression and purification to long-acting formulations.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Recombinant human growth hormone (rhGH) and GH receptor antagonists (GHAs) are used clinically to treat a range of disorders associated with GH deficiency or hypersecretion, respectively. However, these biotherapeutics can be difficult and expensive to manufacture with multiple challenges from recombinant protein generation through to the development of long-acting formulations required to improve the circulating half-life of the drug. In this review, we summarize methodologies and approaches...

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Format

Research paper

Research format

Journal article

Date created

2023-09

Creator

Wang, Yue / Kim, Minah / Buckley, Chantal / Maynard, Heather D / Langley, Ries J / Perry, Jo K

URL

https://hdl.handle.net/2292/66848

Related subjects

Humans / Human Growth Hormone / Receptors, Somatotropin / Recombinant Proteins / PEGylation / antagonist / biotherapeutic / fusion protein / growth hormone / long-acting / recombinant protein production / 3101 Biochemistry and Cell Biology / 3404 Medicinal and Biomolecular Chemistry / 34 Chemical Sciences / 31 Biological Sciences / Rare Diseases / Biotechnology / 5 Development of treatments and therapeutic interventions / 5.1 Pharmaceuticals / Generic health relevance / Science & Technology / Life Sciences & Biomedicine / Biochemistry & Molecular Biology / SITE-SPECIFIC PEGYLATION / HIGH-LEVEL EXPRESSION / PREPARATION NUTROPIN DEPOT / SINGLE-STEP PURIFICATION / P-L PROMOTER / ESCHERICHIA-COLI / PICHIA-PASTORIS / HETEROLOGOUS PROTEIN / INCLUSION-BODIES / HUMAN GH / 0601 Biochemistry and Cell Biology / 0802 Computation Theory and Mathematics / 0899 Other Information and Computing Sciences

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