Phenotype and energy metabolism differ between osteoarthritic chondrocytes from male compared to female patients: Implications for sexual dimorphism in osteoarthritis development?

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Title

Phenotype and energy metabolism differ between osteoarthritic chondrocytes from male compared to female patients: Implications for sexual dimorphism in osteoarthritis development?

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Objectives The prevalence and severity of knee osteoarthritis (OA) is greater in females than males. The purpose of this study was to determine whether there is an underlying difference in the biology of OA chondrocytes from males and females. Methods Chondrocytes were obtained following knee arthroplasty from male and female patients with primary OA. Phenotype marker expression, glucose and fat consumption and rates of glycolysis and oxidative phosphorylation were compared between females an...

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Format

Research paper

Research format

Journal article

Date created

2024

Creator

Jain, Lekha / Jardim, Caitlin / Yulo, Richard / Bolam, Scott / Monk, Paul / Munro, Jacob / Pitto, Rocco / Tamatea, Jade / Dalbeth, Nicola / Poulsen, Raewyn

URL

https://hdl.handle.net/2292/66700

Related subjects

0903 Biomedical Engineering / 1103 Clinical Sciences / 1106 Human Movement and Sports Sciences / 3202 Clinical sciences / 4207 Sports science and exercise

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