MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity

About this item

Title

MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are administered parenterally and are largely ineffective at inducing mucosal immunity. The development of safe and effective mucosal vaccines has been hampered by the lack of a suitable mucosal adjuvant. In this study we explore a class of adjuvant that harnesses mucosal...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2023

Creator

TE Pankhurst / KH Buick / JL Lange / Andrew Marshall / KR Button / OR Palmer / Kathryn Farrand / Isabelle Stewart / TW Bird / NC Mason / J Kuang / Benjamin Compton / Davide Comoletti / M Salio / V Cerundolo / ME Quiñones-Mateu / Gavin Painter / IF Hermans / Lisa Connor

URL

https://figshare.com/articles/journal_contribution/MAIT_cells_activate_dendritic_cells_to_promote...

Related subjects

Biological sciences / Biochemistry and cell biology / Medical physiology / CP: Immunology / IgA / MAIT cell / SARS-CoV-2 / T(FH) cell / adjuvant / dendritic cell / humoral immunity / influenza / mucosal vaccine / Humans / Immunity, Humoral / Mucosal-Associated Invariant T Cells / Antibodies, Viral / COVID-19 / Adjuvants, Immunologic / Immunity, Mucosal / Cell Differentiation / Dendritic Cells / Biological Sciences / Lung / Infectious Diseases / Biotechnology / Pneumonia / Prevention / Vaccine Related / Biodefense / Emerging Infectious Diseases / Immunization / Pneumonia & Influenza / Vaccine Related (AIDS) / .4 Vaccines / Prevention of disease and conditions, and promotion of well-being / Inflammatory and immune system / Infection / Good Health and Well Being

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