Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variants

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Title

Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variants

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Emerging SARS-CoV-2 variants pose a threat to human health worldwide. SARS-CoV-2 receptor binding domain (RBD)-based vaccines are suitable candidates for booster vaccines, eliciting a focused antibody response enriched for virus neutralizing activity. Although RBD proteins are manufactured easily, and have excellent stability and safety properties, they are poorly immunogenic compared to the full-length spike protein. We have overcome this limitation by engineering a subunit vaccine composed ...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2023

Creator

Isabelle Stewart / TW Bird / OR Palmer / NC Mason / TE Pankhurst / B Lawley / LC Hernández / R Harfoot / A Authier-Hall / DE Anderson / Kerry Hilligan / KH Buick / NM Mbenza / G Mittelstädt / S Maxwell / S Sinha / J Kuang / K Subbarao / Emily Parker / A Sher / IF Hermans / JE Ussher / ME Quiñones-Mateu / Davide Comoletti / Lisa Connor

URL

https://figshare.com/articles/journal_contribution/Incorporation_of_SARS-CoV-2_spike_NTD_to_RBD_p...

Related subjects

Biological sciences / Biomedical and clinical sciences / Immunology / Virology / Biological Sciences / Biomedical and Clinical Sciences / Lung / Pneumonia / Biodefense / Biotechnology / Emerging Infectious Diseases / Pneumonia & Influenza / Prevention / Infectious Diseases / Immunization / Vaccine Related / .4 Vaccines / Prevention of disease and conditions, and promotion of well-being / Infection / Good Health and Well Being / VAANZ Group

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