Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers

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Title

Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiotherapy herald new opportunities for classical oxygen-mimetic radiosensitisers. Only nimorazole is used clinically as a radiosensitiser, and there is a dearth of new radiosensitisers in development. In this report, we augment previous work to present ...

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Format

Research paper

Research format

Journal article

Date created

2023-05

Creator

Liew, Lydia P / Shome, Avik / Wong, Way W / Hong, Cho R / Hicks, Kevin O / Jamieson, Stephen MF / Hay, Michael P

URL

https://hdl.handle.net/2292/67728

Related subjects

Humans / Neoplasms / Nitroimidazoles / Radiation-Sensitizing Agents / Cell Hypoxia / Hypoxia / DNA damage / chemoradiotherapy / electron affinity / nitroimidazole / prodrugs / radiosensitisers / radiotherapy / sulfonamide / tumour microenvironment / 3404 Medicinal and Biomolecular Chemistry / 3405 Organic Chemistry / 34 Chemical Sciences / 5 Development of treatments and therapeutic interventions / 5.5 Radiotherapy and other non-invasive therapies / Cancer / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / HYPOXIC CELL RADIOSENSITIZERS / STEREOTACTIC ABLATIVE RADIOTHERAPY / BODY RADIATION-THERAPY / PHASE-III TRIAL / NUCLEOSIDE ANALOG / NECK-CANCER / TUMOR HYPOXIA / EARLY-STAGE / HEAD / CARCINOMA / 0304 Medicinal and Biomolecular Chemistry / 0305 Organic Chemistry / 0307 Theoretical and Computational Chemistry

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