Methods for assessing cardiac myofilament calcium sensitivity.

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Title

Methods for assessing cardiac myofilament calcium sensitivity.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Myofilament calcium (Ca2+) sensitivity is one of several mechanisms by which force production of cardiac muscle is modulated to meet the ever-changing demands placed on the heart. Compromised Ca2+ sensitivity is associated with pathologies, which makes it a parameter of interest for researchers. Ca2+ Sensitivity is the ratio of the association and dissociation rates between troponin C (TnC) and Ca2+. As it is not currently possible to measure these rates in tissue preparations directly, metho...

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Format

Research paper

Research format

Journal article

Date created

2023-01

Creator

Dowrick, Jarrah M / Taberner, Andrew J / Han, June-Chiew / Tran, Kenneth

URL

https://hdl.handle.net/2292/67708

Related subjects

Ca2+ sensitivity / biophysical modelling / calcium / crossbridge / experimental techniques / myofilament / 3208 Medical Physiology / 32 Biomedical and Clinical Sciences / Heart Disease / Cardiovascular / Science & Technology / Life Sciences & Biomedicine / Physiology / SARCOMERE-LENGTH / MYOFIBRILLAR RESPONSIVENESS / MYOCARDIAL-CONTRACTION / INTRACELLULAR CALCIUM / CA-2+ SENSITIVITY / REGULATORY DOMAIN / HEART-FAILURE / TROPONIN-C / FORCE / 0606 Physiology / 1116 Medical Physiology / 1701 Psychology / 3101 Biochemistry and cell biology

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