About this item
- Title
- Combined Inhibition of Phosphodiesterase-5 and -9 in Experimental Heart Failure
- Content partner
- University of Otago
- Collection
- Otago University Research Archive
- Description
Intracellular second messenger cyclic guanosine monophosphate (cGMP) mediates bioactivity of the natriuretic peptides and nitric oxide, and is key to circulatory homeostasis and protection against cardiovascular disease. Inhibition of cGMP-degrading phosphodiesterases (PDEs) PDE5 and PDE9 are emerging as pharmacological targets in heart failure (HF). The present study investigated dual enhancement of cGMP in experimental HF by combining inhibition of PDE-5 (P5-I) and PDE-9 (P9-I). Eight sheep...
- Format
- Research paper
- Research format
- Scholarly text / Journal article
- Thesis level
- Article
- Date created
- 2024-01
- Creator
- Rademaker, Miriam T. / Scott, Nicola J.A. / Charles, Christopher J. / Richards, A. Mark
- URL
- https://hdl.handle.net/10523/19420
- Related subjects
- cyclic guanosine monophosphate / heart failure / natriuretic peptides / nitric oxide / phosphodiesterase 5 / phosphodiesterase 9
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Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 03 May 2024, and updated 09 October 2024.
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