Combined Inhibition of Phosphodiesterase-5 and -9 in Experimental Heart Failure

About this item

Title

Combined Inhibition of Phosphodiesterase-5 and -9 in Experimental Heart Failure

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Intracellular second messenger cyclic guanosine monophosphate (cGMP) mediates bioactivity of the natriuretic peptides and nitric oxide, and is key to circulatory homeostasis and protection against cardiovascular disease. Inhibition of cGMP-degrading phosphodiesterases (PDEs) PDE5 and PDE9 are emerging as pharmacological targets in heart failure (HF). The present study investigated dual enhancement of cGMP in experimental HF by combining inhibition of PDE-5 (P5-I) and PDE-9 (P9-I). Eight sheep...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2024-01

Creator

Rademaker, Miriam T. / Scott, Nicola J.A. / Charles, Christopher J. / Richards, A. Mark

URL

https://hdl.handle.net/10523/19420

Related subjects

cyclic guanosine monophosphate / heart failure / natriuretic peptides / nitric oxide / phosphodiesterase 5 / phosphodiesterase 9

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