Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

About this item

Title

Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire ‘gain-of-function’ isoDGR motifs that might play a role in atherosclerotic pathology. IsoDGR-specific mAb were generated and used for ELISA-based measurement of motif levels in plasma samples from patients with coronary artery diseases (CAD) and non-CAD controls. Functional conseq...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2021-05

Creator

Park, Jung Eun / JebaMercy, Gnanasekaran / Pazhanchamy, Kalailingam / Guo, Xue / Ngan, SoFong Cam / Liou, Ken Cheng Kang / Lynn, Soe EinSi / Ng, Ser Sue / Meng, Wei / Lim, Su Chi / Leow, Melvin Khee-Shing / Richards, A. Mark / Pennington, Daniel J. / de Kleijn, Dominique P.V. / Sorokin, Vitaly / Ho, Hee Hwa / McCarthy, Neil E. / Sze, Siu Kwan

URL

https://hdl.handle.net/10523/21754

Related subjects

Atherosclerosis / Deamidation / Fibronectin / Integrin / isoDGR motif / Vascular inflammation

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