Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction

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Title

Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Whereas heart failure with reduced ejection fraction (HFrEF) is associated with ventricular dilation and markedly reduced systolic function, heart failure with preserved ejection fraction (HFpEF) patients exhibit concentric hypertrophy and diastolic dysfunction. Impaired cardiomyocyte Ca2+ homeostasis in HFrEF has been linked to disruption of membrane invaginations called t-tubules, but it is unknown if such changes occur in HFpEF. This study examined whether distinct cardiomyocyte phenotypes...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2021-02-02

Creator

Frisk, Michael / Le, Christopher / Shen, Xin / Røe, Åsmund T. / Hou, Yufeng / Manfra, Ornella / Silva, Gustavo J.J. / van Hout, Isabelle / Norden, Einar S. / Aronsen, J. Magnus / Laasmaa, Martin / Espe, Emil K.S. / Zouein, Fouad A. / Lambert, Regis R. / Dahl, Christen P. / Sjaastad, Ivar / Lunde, Ida G. / Coffey, Sean / Cataliotti, Alessandro / Gullestad, Lars / Tønnessen, Theis / Jones, Peter P. / Altara, Raffaele / Louch, William E. / Lamberts, Regis

URL

https://hdl.handle.net/10523/21111

Related subjects

calcium cycling/excitation-contraction coupling / heart failure with preserved ejection fraction / pathophysiology / remodeling / transverse tubules / wall stress

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