Research paper

Augmentation of Natriuretic Peptide Bioactivity via Combined Inhibition of Neprilysin and Phosphodiesterase-9 in Heart Failure

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Title
Augmentation of Natriuretic Peptide Bioactivity via Combined Inhibition of Neprilysin and Phosphodiesterase-9 in Heart Failure
Content partner
University of Otago
Collection
Otago University Research Archive
Description

The natriuretic peptides (NPs) are potent natriuretic/diuretic and vasodilatory factors, and augmentation of their levels or signaling via inhibition of the enzymes neprilysin (NEP) and phosphodiesterase 9 (PDE9), respectively, has beneficial actions in heart failure (HF). The authors investigated dual enhancement of NP bioactivity by combining PDE9 inhibition and NEP inhibition in HF using an ovine model. Eight sheep with pacing-induced HF received on 4 separate days intravenous PDE9 inhibit...

Format
Research paper
Research format
Scholarly text / Journal article
Thesis level
Article
Date created
2023-02
Creator
Scott, Nicola J.A. / Prickett, Timothy C.R. / Charles, Christopher J. / Frampton, Christopher M. / Richards, A. Mark / Rademaker, Miriam T.
URL
https://hdl.handle.net/10523/21840
Related subjects
cyclic guanosine monophosphate / heart failure / natriuretic peptides / neprilysin / phosphodiesterase 9

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