Research paper
Augmentation of Natriuretic Peptide Bioactivity via Combined Inhibition of Neprilysin and Phosphodiesterase-9 in Heart Failure
About this item
- Title
- Augmentation of Natriuretic Peptide Bioactivity via Combined Inhibition of Neprilysin and Phosphodiesterase-9 in Heart Failure
- Content partner
- University of Otago
- Collection
- Otago University Research Archive
- Description
The natriuretic peptides (NPs) are potent natriuretic/diuretic and vasodilatory factors, and augmentation of their levels or signaling via inhibition of the enzymes neprilysin (NEP) and phosphodiesterase 9 (PDE9), respectively, has beneficial actions in heart failure (HF). The authors investigated dual enhancement of NP bioactivity by combining PDE9 inhibition and NEP inhibition in HF using an ovine model. Eight sheep with pacing-induced HF received on 4 separate days intravenous PDE9 inhibit...
- Format
- Research paper
- Research format
- Scholarly text / Journal article
- Thesis level
- Article
- Date created
- 2023-02
- Creator
- Scott, Nicola J.A. / Prickett, Timothy C.R. / Charles, Christopher J. / Frampton, Christopher M. / Richards, A. Mark / Rademaker, Miriam T.
- URL
- https://hdl.handle.net/10523/21840
- Related subjects
- cyclic guanosine monophosphate / heart failure / natriuretic peptides / neprilysin / phosphodiesterase 9
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Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 03 May 2024, and updated 09 October 2024.
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