Augmentation of Natriuretic Peptide Bioactivity via Combined Inhibition of Neprilysin and Phosphodiesterase-9 in Heart Failure

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Title

Augmentation of Natriuretic Peptide Bioactivity via Combined Inhibition of Neprilysin and Phosphodiesterase-9 in Heart Failure

Content partner

University of Otago

Collection

Otago University Research Archive

Description

The natriuretic peptides (NPs) are potent natriuretic/diuretic and vasodilatory factors, and augmentation of their levels or signaling via inhibition of the enzymes neprilysin (NEP) and phosphodiesterase 9 (PDE9), respectively, has beneficial actions in heart failure (HF). The authors investigated dual enhancement of NP bioactivity by combining PDE9 inhibition and NEP inhibition in HF using an ovine model. Eight sheep with pacing-induced HF received on 4 separate days intravenous PDE9 inhibit...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2023-02

Creator

Scott, Nicola J.A. / Prickett, Timothy C.R. / Charles, Christopher J. / Frampton, Christopher M. / Richards, A. Mark / Rademaker, Miriam T.

URL

https://hdl.handle.net/10523/21840

Related subjects

cyclic guanosine monophosphate / heart failure / natriuretic peptides / neprilysin / phosphodiesterase 9

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