Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients

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Title

Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Objective Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood, and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migraine and translational models in animals, with emphasis on amylin, a close relative of calcitonin gene-related peptide (CGRP). Methods Thirty-six migraine without aura patients were enrolled in a randomized, double-blind, 2-way, crossover, positive...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2021-06

Creator

Ghanizada, Hashmat / Al-Karagholi, Mohammad Al-Mahdi / Walker, Christopher S. / Arngrim, Nanna / Rees, Tayla / Petersen, Jakeb / Siow, Andrew / Morch-Rasmussen, Mette / Tan, Sheryl / O'Carroll, Simon J. / Harris, Paul / Skovgaard, Lene Theil / Jorgensen, Niklas Rye / Brimble, Margaret / Waite, Jayme S. / Rea, Brandon J. / Sowers, Levi P. / Russo, Andrew F. / Hay, Debbie L. / Ashina, Messoud

URL

https://hdl.handle.net/10523/17543

Related subjects

Clinical Neurology / Life Sciences & Biomedicine / Neurosciences / Neurosciences & Neurology / Science & Technology

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