About this item

Title

Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Systemic microvascular dysfunction and inflammation are postulated to play a pathophysiologic role in heart failure with preserved ejection fraction (HFpEF). This study aimed to identify biomarker profiles associated with clinical outcomes in HFpEF and investigate how inhibition of the neutrophil-derived reactive oxygen species–producing enzyme, myeloperoxidase, affects these biomarkers. Using supervised principal component analyses, the investigators assessed the associations between baselin...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2023-07-01

Creator

Michaëlsson, Erik / Lund, Lars H. / Hage, Camilla / Shah, Sanjiv J. / Voors, Adriaan A. / Saraste, Antti / Redfors, Björn / Grove, Erik L. / Barasa, Anders / Richards, A. Mark / Svedlund, Sara / Lagerström-Fermér, Maria / Gabrielsen, Anders / Garkaviy, Pavlo / Gan, Li-Ming / Lam, Carolyn S.P.

URL

https://hdl.handle.net/10523/21198

Related subjects

AZD4831 / heart failure / HFpEF / inflammation / microvascular dysfunction / myeloperoxidase

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