Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin

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Title

Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Etimicin (ETM), a fourth-generation aminoglycosides (AGs), is now widely clinically used in China due to its high efficacy and low toxicity. However, the mechanisms underlying its low nephrotoxicity and ototoxicity remain unclear. In the present study we compared the antibacterial and toxicity profiles of etimicin, gentamicin (GM, a second-generation AG), and amikacin (AMK, a third-generation AG), and investigated their pharmacokinetic properties in the toxicity target organs (kidney and inne...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2020-06-01

Creator

Yao, Lan / Zhang, Jing-Wei / Chen, Bin / Cai, Ming-Min / Feng, Dong / Wang, Qi-Zhi / Wang, Xin-Yu / Sun, Jian-Guo / Zheng, Yi-Wen / Wang, Guang-Ji / Zhou, Fang

URL

https://hdl.handle.net/10523/17383

Related subjects

Aminoglycosides - administration & dosage / Aminoglycosides - chemistry / Aminoglycosides - pharmacokinetics / Aminoglycosides - toxicity / Animals / Anti-Bacterial Agents - administration & dosage / Anti-Bacterial Agents - chemistry / Anti-Bacterial Agents - pharmacokinetics / Anti-Bacterial Agents - toxicity / Ear, Inner - drug effects / Ear, Inner - pathology / Enterobacter cloacae - drug effects / Escherichia coli - drug effects / Injections, Intraperitoneal / Kidney - drug effects / Kidney - pathology / Klebsiella pneumoniae - drug effects / Male / Microbial Sensitivity Tests / Mitochondria - drug effects / Proteus mirabilis - drug effects / Pseudomonas aeruginosa - drug effects / Rats / Rats, Sprague-Dawley / Staphylococcus aureus - drug effects

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