Host Defense Peptide-Mimicking Amphiphilic β-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity

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Title

Host Defense Peptide-Mimicking Amphiphilic β-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Therapeutic options to treat multidrug resistant bacteria, especially when present in biofilms, are limited due to their high levels of antibiotic resistance. Here, we report the anti-biofilm and immunomodulatory activities of the host defense peptide (HDP)-mimicking β-peptide polymer (20:80 Bu:DM) and investigated its activity . The polymer outperformed antibiotics in the removal and reduction of the viability of established biofilms, achieving a maximum activity of around 80% reduction in v...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2020-11-12

Creator

Etayash, Hashem / Qian, Yuxin / Pletzer, Daniel / Zhang, Qiang / Xie, Jiayang / Cui, Ruxin / Dai, Chengzhi / Ma, Pengcheng / Qi, Fan / Liu, Runhui / Hancock, Robert E W

URL

https://hdl.handle.net/10523/19595

Related subjects

Animals / Anti-Bacterial Agents - pharmacology / Anti-Infective Agents - chemistry / Anti-Infective Agents - pharmacology / Anti-Infective Agents - therapeutic use / Antimicrobial Cationic Peptides - chemistry / Biofilms - drug effects / Cell Survival - drug effects / Cytokines - pharmacology / Disease Models, Animal / Humans / Immunity, Innate - drug effects / Leukocytes, Mononuclear - cytology / Leukocytes, Mononuclear - drug effects / Leukocytes, Mononuclear - metabolism / Methicillin-Resistant Staphylococcus aureus / Microbial Sensitivity Tests / Peptidomimetics / Polymers - chemistry / Polymers - pharmacology / Polymers - therapeutic use / Pseudomonas aeruginosa - drug effects / Pseudomonas aeruginosa - physiology / Skin Diseases - drug therapy / Skin Diseases - microbiology / Skin Diseases - pathology

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