Human organoid biofilm model for assessing antibiofilm activity of novel agents

About this item

Title

Human organoid biofilm model for assessing antibiofilm activity of novel agents

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with robust methicillin-resistant Staphylococcus aureus (MRSA) USA300 and Pseudomonas aeruginosa PAO1 biofilm was developed. Treatment of 1-day and 3-day MRSA and PAO1 biofilms with antibiofilm peptide DJK-5 sig...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2021-01-25

Creator

Wu, Bing Catherine / Haney, Evan F / Akhoundsadegh, Noushin / Pletzer, Daniel / Trimble, Michael J / Adriaans, Alwin E / Nibbering, Peter H / Hancock, Robert E W

URL

https://hdl.handle.net/10523/19347

Related subjects

Anti-Bacterial Agents - pharmacology / Anti-Bacterial Agents - therapeutic use / Anti-Inflammatory Agents - pharmacology / Anti-Inflammatory Agents - therapeutic use / Bacterial Load - drug effects / Biofilms - drug effects / Biofilms - growth & development / Burns - drug therapy / Burns - immunology / Burns - microbiology / Drug Evaluation, Preclinical / Drug Therapy, Combination / Humans / Methicillin-Resistant Staphylococcus aureus - drug effects / Models, Biological / Oligopeptides - pharmacology / Oligopeptides - therapeutic use / Organoids - drug effects / Organoids - immunology / Organoids - injuries / Organoids - microbiology / Pseudomonas aeruginosa - drug effects / Skin - drug effects / Skin - immunology / Skin - injuries / Skin - microbiology

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