Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis

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Title

Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis

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University of Otago

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Otago University Research Archive

Description

Enterococcus faecalis is a gram-positive organism responsible for serious infections in humans, but as with many bacterial pathogens, resistance has rendered a number of commonly used antibiotics ineffective. Here, we report the cryo-EM structure of the E. faecalis 70S ribosome to a global resolution of 2.8 Å. Structural differences are clustered in peripheral and solvent exposed regions when compared with Escherichia coli , whereas functional centres, including antibiotic binding sites, are ...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2020-10-01

Creator

Murphy, Eileen L. / Singh, Kavindra V. / Avila, Bryant / Kleffmann, Torsten / Gregory, Steven T. / Murray, Barbara E. / Krause, Kurt L. / Khayat, Reza / Jogl, Gerwald

URL

https://hdl.handle.net/10523/19648

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