Changes in glutamate and glutamine distributions in the retinas of cystine/glutamate antiporter knockout mice.

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Title

Changes in glutamate and glutamine distributions in the retinas of cystine/glutamate antiporter knockout mice.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Purpose: The cystine/glutamate antiporter is involved in the export of intracellular glutamate in exchange for extracellular cystine. Glutamate is the main neurotransmitter in the retina and plays a key metabolic role as a major anaplerotic substrate in the tricarboxylic acid cycle to generate adenosine triphosphate (ATP). In addition, glutamate is also involved in the outer plexiform glutamate-glutamine cycle, which links photoreceptors and supporting Müller cells and assists in maintaining ...

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Format

Research paper

Research format

Journal article

Creator

Knight, Luis J / Martis, Renita M / Donaldson, Paul J / Acosta, Monica L / Lim, Julie C

URL

https://hdl.handle.net/2292/68212

Related subjects

Retina / Animals / Mice, Inbred C57BL / Mice, Knockout / Mice / Cystine / gamma-Aminobutyric Acid / Lactate Dehydrogenases / Glutamic Acid / Glutamine / Glycine / Antiporters / Adenosine Triphosphate / Neurotransmitter Agents / 32 Biomedical and Clinical Sciences / 3212 Ophthalmology and Optometry / Neurosciences / Eye Disease and Disorders of Vision / 2 Aetiology / 2.1 Biological and endogenous factors / Science & Technology / Life Sciences & Biomedicine / Biochemistry & Molecular Biology / Ophthalmology / AMINO-ACID NEUROTRANSMITTERS / AMACRINE CELLS / ENERGY-METABOLISM / RAT / LOCALIZATION / CYCLE / IMMUNOREACTIVITY / PHOTORECEPTORS / DEHYDROGENASE / TRANSPORTER / 1113 Opthalmology and Optometry

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