SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial.

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Title

SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial.

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The University of Auckland Library

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Description

IntroductionSulforaphane can induce the transcription factor, Nrf2, promoting antioxidant and anti-inflammatory responses. In this study, hospitalised patients with community-acquired pneumonia (CAP) were treated with stabilised synthetic sulforaphane (SFX-01) to evaluate impact on clinical status and inflammation.MethodsDouble-blind, randomised, placebo-controlled trial of SFX-01 (300 mg oral capsule, once daily for 14 days) conducted in Dundee, UK, between November 2020 and May 2021. Patien...

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Format

Research paper

Research format

Journal article

Creator

Long, Merete B / Abo-Leyah, Hani / Giam, Yan Hui / Vadiveloo, Thenmalar / Hull, Rebecca C / Keir, Holly R / Pembridge, Thomas / Alferes De Lima, Daniela / Delgado, Lilia / Inglis, Sarah K / Hughes, Chloe / Gilmour, Amy / Gierlinski, Marek / New, Benjamin JM / MacLennan, Graeme / Dinkova-Kostova, Albena T / Chalmers, James D

URL

https://hdl.handle.net/2292/68314

Related subjects

32 Biomedical and Clinical Sciences / 3202 Clinical Sciences / Prevention / Lung / Complementary and Integrative Health / Pneumonia / Infectious Diseases / Genetics / Clinical Research / Pneumonia & Influenza / Clinical Trials and Supportive Activities / 6.1 Pharmaceuticals / 6 Evaluation of treatments and therapeutic interventions / Infection / 3 Good Health and Well Being / 3201 Cardiovascular medicine and haematology / 3211 Oncology and carcinogenesis

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