Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model.

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Title

Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model.

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

Multi-scale mathematical bioelectrical models of organs such as the uterus, stomach or heart present challenges both for accuracy and computational tractability. These multi-scale models are typically founded on models of biological cells derived from the classic Hodkgin-Huxley (HH) formalism. Ion channel behaviour is tracked with dynamical variables representing activation or inactivation of currents that relax to steady-state dependencies on cellular membrane voltage. Timescales for relaxat...

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Format

Research paper

Research format

Journal article

Creator

Means, Shawn A / Roesler, Mathias W / Garrett, Amy S / Cheng, Leo / Clark, Alys R

URL

https://hdl.handle.net/2292/68321

Related subjects

Heart / Cell Membrane / Myocytes, Smooth Muscle / Reed-Sternberg Cells / Humans / Action Potentials / Female / 3208 Medical Physiology / 32 Biomedical and Clinical Sciences / Bioengineering / 1.1 Normal biological development and functioning / 1 Underpinning research / Science & Technology / Life Sciences & Biomedicine / Biochemical Research Methods / Mathematical & Computational Biology / Biochemistry & Molecular Biology / CURRENTS / REPOLARIZATION / EXCITATION / MYOCYTES / 01 Mathematical Sciences / 06 Biological Sciences / 08 Information and Computing Sciences

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