Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide

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Title

Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate the impact of the metal center on the anticancer activity and their physicochemical properties, the Os(cym), Rh- and Ir(Cp*) (Cp* = pentamethylcyclopentadienyl) analogues of the most promising and orally active compound plecstatin 2 were prepared ...

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Format

Research paper

Research format

Journal article

Creator

Arshad, Jahanzaib / Tong, Kelvin KH / Movassaghi, Sanam / Söhnel, Tilo / Jamieson, Stephen MF / Hanif, Muhammad / Hartinger, Christian G

URL

https://hdl.handle.net/2292/68665

Related subjects

Cell Line, Tumor / Humans / Ruthenium / Thioamides / Organometallic Compounds / Pyridines / Antineoplastic Agents / Ligands / Cell Proliferation / Molecular Conformation / Structure-Activity Relationship / Models, Molecular / anticancer agents / bioorganometallics / iridium / metal complexes / metallodrugs / pyridinecarbothioamide / rhodium / 3402 Inorganic Chemistry / 34 Chemical Sciences / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / ORGANORUTHENIUM / 2-PYRIDINECARBOTHIOAMIDES / LIGAND / DRUGS / RU / 0304 Medicinal and Biomolecular Chemistry / 0305 Organic Chemistry / 0307 Theoretical and Computational Chemistry / 3404 Medicinal and biomolecular chemistry / 3405 Organic chemistry

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