High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes

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Title

High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes

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Description

Hydroxypyr(id)ones are a pharmaceutically important class of compounds that have shown potential in diverse areas of drug discovery. We investigated the 3-hydroxy-4-pyridones 1a-1c and 3-hydroxy-4-thiopyridones 1d-1f as well as their Ru(η6-p-cymene)Cl complexes 2a-2f, and report here the molecular structures of 1b and 1d as determined by X-ray diffraction analysis. Detailed cell biological investigations revealed potent cytotoxic activity, in particular of the 3-hydroxy-4-thiopyridones 1d-1f,...

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Format

Research paper

Research format

Journal article

Creator

Shakil, Md Salman / Parveen, Shahida / Rana, Zohaib / Walsh, Fearghal / Movassaghi, Sanam / Söhnel, Tilo / Azam, Mayur / Shaheen, Muhammad Ashraf / Jamieson, Stephen MF / Hanif, Muhammad / Rosengren, Rhonda J / Hartinger, Christian G

URL

https://hdl.handle.net/2292/68669

Related subjects

3-hydroxy-4-pyridone / 3-hydroxy-4-thiopyridone / Ru(arene) complexes / anticancer agents / apoptosis / cytotoxicity / 3402 Inorganic Chemistry / 34 Chemical Sciences / Cancer / Science & Technology / Life Sciences & Biomedicine / Biochemistry & Molecular Biology / Medicine, Research & Experimental / Pharmacology & Pharmacy / Research & Experimental Medicine / 3101 Biochemistry and cell biology / 3214 Pharmacology and pharmaceutical sciences / 3404 Medicinal and biomolecular chemistry

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