Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands

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Title

Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Ispinesib is a potent inhibitor of kinesin spindle protein (KSP), which has been identified as a promising target for antimitotic anticancer drugs. Herein, we report the synthesis of half-sandwich complexes of Ru, Os, Rh, and Ir bearing the ispinesib-derived N,N-bidentate ligands (R)- and (S)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one and studies on their chemical and biological properties. Using the enantiomerically pure (R)- and (S)-forms of the ligand, depending on th...

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Format

Research paper

Research format

Journal article

Creator

Łomzik, Michał / Hanif, Muhammad / Budniok, Aleksandra / Błauż, Andrzej / Makal, Anna / Tchoń, Daniel M / Leśniewska, Barbara / Tong, Kelvin KH / Movassaghi, Sanam / Söhnel, Tilo / Jamieson, Stephen MF / Zafar, Ayesha / Reynisson, Jóhannes / Rychlik, Błażej / Hartinger, Christian G / Plażuk, Damian

URL

https://hdl.handle.net/2292/68569

Related subjects

Cell Line, Tumor / Humans / Metals, Heavy / Benzamides / Quinazolines / Antineoplastic Agents / Antioxidants / Ligands / Drug Screening Assays, Antitumor / Cell Proliferation / Protein Binding / Stereoisomerism / Coordination Complexes / Molecular Docking Simulation / Kinesins / 3402 Inorganic Chemistry / 34 Chemical Sciences / Cancer / Science & Technology / Physical Sciences / Chemistry, Inorganic & Nuclear / Chemistry / RUTHENIUM COMPLEXES / ANTICANCER AGENTS / CRYSTAL-STRUCTURE / DERIVATIVES / PACLITAXEL / TAXANES / PYRIMIDINE / COLCHICINE / ANALOGS / 0302 Inorganic Chemistry / 0306 Physical Chemistry (incl. Structural) / 0399 Other Chemical Sciences / 3403 Macromolecular and materials chemistry

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