Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice

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Title

Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Pharmacological treatments can extend the life span of mice. For optimal translation in humans, treatments should improve health during aging, and demonstrate efficacy when started later in life. Acarbose (ACA) and rapamycin (RAP) extend life span in mice when treatment is started early or later in life. Both drugs can also improve some indices of healthy aging, although there has been little systematic study of whether health benefits accrue differently depending on the age at which treatmen...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2023-03-01

Creator

Herrera, Jonathan J / Pifer, Kaitlyn / Louzon, Sean / Leander, Danielle / Fiehn, Oliver / Day, Sharlene M / Miller, Richard A / Garratt, Michael

URL

https://hdl.handle.net/10523/23248

Related subjects

Acarbose - pharmacology / Aging / Animals / Female / Humans / Longevity / Male / Mice / Physical Functional Performance / Sirolimus - pharmacology

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