Synthesis, Structure-Activity Relationship Study, Bioactivity, and Nephrotoxicity Evaluation of the Proposed Structure of the Cyclic Lipodepsipeptide Brevicidine B

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Title

Synthesis, Structure-Activity Relationship Study, Bioactivity, and Nephrotoxicity Evaluation of the Proposed Structure of the Cyclic Lipodepsipeptide Brevicidine B

Content partner

University of Otago

Collection

Otago University Research Archive

Description

The brevicidines represent a novel class of nonribosomal antimicrobial peptides that possess remarkable potency and selectivity toward highly problematic and resistant Gram-negative pathogenic bacteria. A recently discovered member of the brevicidine family, coined brevicidine B ( ), comprises a single amino acid substitution (from d-Tyr to d-Phe ) in the amino acid sequence of the linear moiety of brevicidine ( ) and was reported to exhibit broader antimicrobial activity against both Gram-ne...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2024-04-26

Creator

Palpal-Latoc, Dennise / Horsfall, Aimee J / Cameron, Alan J / Campbell, Georgia / Ferguson, Scott A / Cook, Gregory M / Sander, Veronika / Davidson, Alan J / Harris, Paul W R / Brimble, Margaret A

URL

https://hdl.handle.net/10523/24244

Related subjects

Anti-Bacterial Agents - chemical synthesis / Anti-Bacterial Agents - chemistry / Anti-Bacterial Agents - pharmacology / Depsipeptides - chemical synthesis / Depsipeptides - chemistry / Depsipeptides - pharmacology / Escherichia coli - drug effects / Gram-Negative Bacteria - drug effects / Gram-Positive Bacteria - drug effects / Humans / Klebsiella pneumoniae - drug effects / Microbial Sensitivity Tests / Molecular Structure / Peptides, Cyclic - chemical synthesis / Peptides, Cyclic - chemistry / Peptides, Cyclic - pharmacology / Pseudomonas aeruginosa - drug effects / Structure-Activity Relationship

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