Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of Amoxicillin

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Title

Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of Amoxicillin

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers. This study aimed to evaluate the rectal bioavailability of hollow-type suppositories (HTS) and understand the effect of two chemical forms of amoxicillin: amoxicillin sodium (AS) or amoxicillin trihydrate (AMT). HTS were prepared by incorporating a lipophilic core containing the antibiotic with a polyethyl...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2023-07-01

Creator

Purohit, Trusha J / Amirapu, Satya / Wu, Zimei / Hanning, Sara M

URL

https://hdl.handle.net/10523/24206

Related subjects

rectal drug delivery / amoxicillin / tissue tolerance / bioavailability / hollow-type suppositories / stability

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