Recombinant horseradish peroxidase variants for targeted cancer treatment

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Title

Recombinant horseradish peroxidase variants for targeted cancer treatment

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Cancer is a major cause of death. Common chemo- and radiation-therapies damage healthy tissue and cause painful side effects. The enzyme horseradish peroxidase (HRP) has been shown to activate the plant hormone indole-3-acetic acid (IAA) to a powerful anticancer agent in in vitro studies, but gene directed enzyme prodrug therapy (GDEPT) studies showed ambivalent results. Thus, HRP/IAA in antibody directed enzyme prodrug therapy (ADEPT) was investigated as an alternative. However, this approac...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2016-06

Creator

Bonifert, Günther / Folkes, Lisa / Gmeiner, Christoph / Dachs, Gabi / Spadiut, Oliver

URL

https://hdl.handle.net/10523/29475

Related subjects

Antineoplastic Agents - chemistry / Antineoplastic Agents - isolation & purification / Antineoplastic Agents - pharmacology / Cell Line, Tumor / Cell Survival - drug effects / Enzyme Activation - drug effects / Horseradish Peroxidase - chemistry / Horseradish Peroxidase - isolation & purification / Horseradish Peroxidase - pharmacology / Humans / Indoleacetic Acids - chemistry / Inhibitory Concentration 50 / Isoenzymes / Prodrugs / Recombinant Proteins - chemistry / Recombinant Proteins - isolation & purification / Recombinant Proteins - pharmacology

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