Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils

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Title

Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Periodontal disease is a prevalent chronic inflammatory condition characterised by an aberrant host response to a pathogenic plaque biofilm resulting in local tissue damage and frustrated healing that can result in tooth loss. Cysteine proteases (gingipains) from the key periodontal pathogen Porphyromonas gingivalis have been implicated in periodontal disease pathogenesis by inhibiting inflammation resolution and are linked with systemic chronic inflammatory conditions such as rheumatoid arth...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2017-03-02

Creator

Castro, Sowmya A / Collighan, Russell / Lambert, Peter A / Dias, Irundika Hk / Chauhan, Parbata / Bland, Charlotte E / Milic, Ivana / Milward, Michael R / Cooper, Paul R / Devitt, Andrew

URL

https://hdl.handle.net/10523/26369

Related subjects

Adhesins, Bacterial - metabolism / Apoptosis - physiology / Bacteroidaceae Infections - metabolism / Bacteroidaceae Infections - microbiology / Bacteroidaceae Infections - pathology / Biofilms - growth & development / Cell Line, Tumor / Cell Movement - physiology / Cysteine Endopeptidases - metabolism / Cysteine Proteases - metabolism / Humans / Inflammation - metabolism / Inflammation - microbiology / Inflammation - pathology / Lipopolysaccharide Receptors - metabolism / Lipopolysaccharides - metabolism / Macrophages - metabolism / Macrophages - pathology / Neutrophils - metabolism / Neutrophils - microbiology / Neutrophils - pathology / Phagocytosis - physiology / Porphyromonas gingivalis - metabolism / Tumor Necrosis Factor-alpha - metabolism

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