Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy

About this item

Title

Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Microangiopathy due to endothelial dysfunction is a major contributing factor to the development of diabetes-induced cardiovascular disease (CVD). Dysregulation of endothelial-specific microRNAs (miRs) is correlated with impaired angiogenesis and cell survival. We investigated the profile of two angiomiRs, miR-126, and miR-132, in the plasma of type 2 diabetic individuals without any known history of CVD as well as in the cardiac tissues collected from diabetics undergoing cardiac surgery. Th...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2017-01

Creator

Rawal, Shruti / Munasinghe, Pujika Emani / Shindikar, Amol / Paulin, Jono / Cameron, Vicky / Manning, Patrick / Williams, Michael J A / Jones, Gregory T / Bunton, Richard / Galvin, Ivor / Katare, Rajesh

URL

https://hdl.handle.net/10523/26194

Related subjects

Animals / Apoptosis / Coronary Artery Disease - etiology / Coronary Artery Disease - genetics / Coronary Artery Disease - metabolism / Coronary Artery Disease - pathology / Coronary Vessels - metabolism / Coronary Vessels - pathology / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - genetics / Diabetes Mellitus, Type 2 - metabolism / Diabetic Angiopathies - etiology / Diabetic Angiopathies - genetics / Diabetic Angiopathies - metabolism / Diabetic Angiopathies - pathology / Disease Models, Animal / Down-Regulation / HEK293 Cells / Human Umbilical Vein Endothelial Cells - metabolism / Human Umbilical Vein Endothelial Cells - pathology / Humans / Mice, Inbred C57BL / MicroRNAs - blood / MicroRNAs - genetics / MicroRNAs - metabolism / Myocardium - metabolism / Neovascularization, Physiologic / Signal Transduction / Time Factors / Tissue Culture Techniques / Transfection

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