Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability

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Title

Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Lithium is the mainstay treatment for patients with bipolar disorder, but it generally causes nephrogenic diabetes insipidus (NDI), a disorder in which the renal urine concentrating ability has become vasopressin insensitive. Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of aquaporin-2 (AQP2) water channels, which are essential for water uptake from tubular urine. Recently, we found that the prophylactic administration of acetazolamide to mice effect...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2017-09-01

Creator

de Groot, Theun / Doornebal, Joan / Christensen, Birgitte M / Cockx, Simone / Sinke, Anne P / Baumgarten, Ruben / Bedford, Jennifer J / Walker, Robert J / Wetzels, Jack F M / Deen, Peter M T

URL

https://hdl.handle.net/10523/28134

Related subjects

Acetazolamide - adverse effects / Acetazolamide - therapeutic use / Aged / Animals / Aquaporin 2 - metabolism / Blood Pressure - drug effects / Diabetes Insipidus, Nephrogenic - chemically induced / Diabetes Insipidus, Nephrogenic - drug therapy / Diabetes Insipidus, Nephrogenic - physiopathology / Disease Models, Animal / Diuretics - adverse effects / Diuretics - therapeutic use / Female / Glomerular Filtration Rate - drug effects / Humans / Kidney - drug effects / Kidney - metabolism / Kidney - physiopathology / Kidney Concentrating Ability - drug effects / Lithium Chloride / Male / Mice, Inbred C57BL / Middle Aged / Netherlands / New Zealand / Osmolar Concentration / Pilot Projects / Polyuria - chemically induced / Polyuria - drug therapy / Polyuria - physiopathology / Prospective Studies / Time Factors / Treatment Outcome

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