Research paper
HDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression without Affecting Cohesin-dependent Transcription in MCF7 Cancer Cells
About this item
- Title
- HDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression without Affecting Cohesin-dependent Transcription in MCF7 Cancer Cells
- Content partner
- University of Otago
- Collection
- Otago University Research Archive
- Description
Cohesin, a multi-subunit protein complex involved in chromosome organization, is frequently mutated or aberrantly expressed in cancer. Multiple functions of cohesin, including cell division and gene expression, highlight its potential as a novel therapeutic target. The SMC3 subunit of cohesin is acetylated (ac) during S phase to establish cohesion between replicated chromosomes. Following anaphase, ac-SMC3 is deacetylated by HDAC8. Reversal of SMC3 acetylation is imperative for recycling cohe...
- Format
- Research paper
- Research format
- Scholarly text / Journal article
- Thesis level
- Article
- Date created
- 2016-06-10
- Creator
- Dasgupta, Tanushree / Antony, Jisha / Braithwaite, Antony W. / Horsfield, Julia A.
- URL
- https://hdl.handle.net/10523/29460
- Related subjects
- breast cancer / cell cycle / cohesin / estrogen receptor / gene expression / HDAC8 / histone deacetylase inhibitor (HDAC inhibitor) (HDI) / SMC3
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Copyright © The Author(s) 2016. This work was first published in Journal of Biological Chemistry (Elsevier). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://www.creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, provided that the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
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