A Novel Role for Somatostatin in the Survival of Mouse Pancreatic Beta Cells

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Title

A Novel Role for Somatostatin in the Survival of Mouse Pancreatic Beta Cells

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Cross-talk between different pancreatic islet cell types regulates islet function and somatostatin (SST) released from pancreatic delta cells inhibits insulin secretion from pancreatic beta cells. In other tissues SST exhibits both protective and pro-apoptotic properties in a tissue-specific manner, but little is known about the impact of the peptide on beta cell survival. Here we investigate the specific role of SST in the regulation of beta cell survival in response to physiologically relev...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2019

Creator

Damsteegt, Erin L / Hassan, Zoheb / Hewawasam, Nirun V / Sarnsamak, Kittiwadee / Jones, Peter M / Hauge-Evans, Astrid C

URL

https://hdl.handle.net/10523/26295

Related subjects

Animals / Apoptosis - drug effects / Caspase 3 - genetics / Caspase 3 - metabolism / Caspase 7 - genetics / Caspase 7 - metabolism / Cell Line / Cell Proliferation - drug effects / Chemokine CCL2 - genetics / Chemokine CCL2 - metabolism / Gene Expression Regulation / Glucose - antagonists & inhibitors / Glucose - pharmacology / HSP70 Heat-Shock Proteins - genetics / HSP70 Heat-Shock Proteins - metabolism / Insulin-Secreting Cells - cytology / Insulin-Secreting Cells - drug effects / Insulin-Secreting Cells - metabolism / Interleukin-1beta - antagonists & inhibitors / Interleukin-1beta - pharmacology / Islets of Langerhans - drug effects / Islets of Langerhans - metabolism / Male / Mice / Mice, Inbred ICR / NF-kappa B - genetics / NF-kappa B - metabolism / Nitric Oxide Synthase Type II - genetics / Nitric Oxide Synthase Type II - metabolism / Palmitic Acid - antagonists & inhibitors / Palmitic Acid - pharmacology / Pertussis Toxin - antagonists & inhibitors / Pertussis Toxin - pharmacology / Somatostatin - pharmacology / Tissue Culture Techniques / Transcription Factor CHOP - genetics / Transcription Factor CHOP - metabolism / Tumor Necrosis Factor-alpha - antagonists & inhibitors / Tumor Necrosis Factor-alpha - pharmacology

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